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Abstract Objective We set out to test the discriminative power of an age-adjusted upper reference limit for cerebrospinal fluid total protein CSF-TP in identifying clinically relevant causes of albuminocytological dissociation ACD. Methods We reviewed the charts of patients who underwent a lumbar puncture at a tertiary care centre over a year period. Adjustment for sex was not applied to the age-adjusted norms although the importance of gender has been previously described.
Results The presence of ACD was associated with a broad range of neurological diagnoses. Use of an age-adjusted upper reference limit favoured the detection of polyneuropathy patients Charts were thoroughly evaluated for potential sources of albuminocytological dissociation ACD including the review consultation notes, neuroimaging and laboratory data.
Factors previously described to vary with CSF-TP such as sex, body mass index, CSF sample number or lifestyle factors smoking, alcohol or physical activity were not explored as much of these data were unavailable at the time of analysis. In the current study, we hypothesised that the implementation of age-adjusted upper reference limits URLs would result in a larger proportion of identified patients with expectedly high CSF-TP protein—including those with inflammatory neuropathies.
We, therefore, sought to describe the types of clinical diagnoses associated with ACD. Samples with incomplete clinical or laboratory data, or those performed on paediatric patients were also excluded.
ALBUMINOCYTOLOGICAL DISSOCIATION PDF
Statistical analysis was performed using the commercial program SPSS Mann-Whitney U test was used to compare the data of the groups. Correlation analysis was performed using the Spearman correlation test. Results Clinical and laboratory findings of the patients are described in Table 2. According to the clinical and electrophysiological findings, 25 Twenty The mean age of the 36 patients was
Clinical features and prognosis with Guillain-Barré syndrome