Montville a , Ingolf F. Nes b, Michael L. N As, Norway Received 31 January ; received in revised form 10 May ; accepted 11 June Abstract Bacteriocins are antibacterial proteins produced by bacteria that kill or inhibit the growth of other bacteria. Many lactic acid bacteria? Though these bacteriocins are produced by LAB found in numerous fermented and non-fermented foods, nisin is currently the only bacteriocin widely used as a food preservative. Many bacteriocins have been characterized biochemically and genetically, and though there is a basic understanding of their structure—function, biosynthesis, and mode of action, many aspects of these compounds are still unknown.
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Received Mar 20; Accepted May 2. The use, distribution or reproduction in other forums is permitted, provided the original author s or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. This article has been corrected. See Front Microbiol. This article has been cited by other articles in PMC.
Abstract Bacteriocins are a kind of ribosomal synthesized antimicrobial peptides produced by bacteria, which can kill or inhibit bacterial strains closely-related or non-related to produced bacteria, but will not harm the bacteria themselves by specific immunity proteins. Bacteriocins become one of the weapons against microorganisms due to the specific characteristics of large diversity of structure and function, natural resource, and being stable to heat. Many recent studies have purified and identified bacteriocins for application in food technology, which aims to extend food preservation time, treat pathogen disease and cancer therapy, and maintain human health.
Therefore, bacteriocins may become a potential drug candidate for replacing antibiotics in order to treat multiple drugs resistance pathogens in the future. This review article summarizes different types of bacteriocins from bacteria. The latter half of this review focuses on the potential applications in food science and pharmaceutical industry. Keywords: bacteriocin, protein, natural product, food, cancer treatment Introduction There are many antibacterial substances produced by animals, plants, insects, and bacteria, such as hydrogen peroxide, fatty acids, organic acids, ethanol, antibiotics, and bacteriocins.
Antimicrobial peptides AMPs or proteins produced by bacteria are categorized as bacteriocins. Scant nutrients in the environment trigger microbial production of a variety of bacteriocins for competition of space and resources. The killing ability of bacteriocins is considered a successful strategy for maintaining population and reducing the numbers of competitors to obtain more nutrients and living space in environments. Unlike most antibiotics, which are secondary metabolites, bacteriocins are ribosomally synthesized and sensitive to proteases while generally harmless to the human body and surrounding environment.
No document with DOI "10.1.1.706.4954"
According to the report of WHO in , there were about 1. The main cause of food-borne illnesses is the use of food contaminated by microbial pathogens, toxins, or radioactive components. Food-borne pathogens Clostridium botulinum, Staphylococcus aureus, Campylobacter jejuni, Bacillus cereus, Listeria monocytogenes, Cryptosporidium, Escherichia coli OH7, etc. Food can contain microbiological pathogens that cause infections or intoxications, or chemical agents that cause acute or chronic intoxications. With special reference to meat and meat products, Salmonella, E.
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